1) I verified the login parameters as they work fine in PayPal manager.
2) It worked fine for a year with AspDotNetStoreFront.
3) Allow IP is being used and called from an allowed IP. (See #2)
4) I am using the actual paypal website (payflowpro.paypal.com) and Smith Cart test mode is not checked.
Note that I am using an actual credit card # and valid CCV2.
PayFlowPro Status: Your account is currently in ACTIVE status. You can run both live and test transactions.